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Updated: Jul 8, 2025

Quantitative Comparison of cis-Regulatory Element CRE Activities in Transgenic Drosophila melanogaster
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Quantitative Comparison of cis-Regulatory Element CRE Activities in Transgenic Drosophila melanogaster

Published on: December 19, 2011

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一种Drosophila的序列依赖性是一个上下文依赖的转录因子

Lauren J Hodkinson1, Julia Gross2, Casey A Schmidt3

  • 1Genetics and Molecular Biology Graduate Program, Emory University, Atlanta, GA 30322 USA.

bioRxiv : the preprint server for biology
|December 18, 2023
PubMed
概括

像CLAMP这样的转录因子可以根据它们的位置执行不同的功能. CLAMP使用DNA序列和局部基因组环境来进行特定环境的基因调节.

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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