在非透析依赖的5期慢性病患者中,异常结构功能网络合与认知衰退的关联
Lijun Song1, Xu Liu2, Wenbo Yang1
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Quantitative imaging in medicine and surgery
|December 18, 2023
概括
慢性病 (CKD) 5期患者表现出大脑网络拓和结构功能合的改变,与认知障碍有关. 这些大脑网络的变化与认知得分相关,为CKD相关的认知衰退提供了见解.
科学领域:
- 神经科学是一个神经科学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 医疗成像医学成像
背景情况:
- 在慢性病 (CKD) 中,认知能力下降很普遍,特别是在第5阶段.
- 连接CKD和认知障碍的机制仍然不清楚.
- 结构功能合提供了一种新的方法来研究CKD中大脑网络的改变.
研究的目的:
- 在非透析依赖的5期CKD (CKD 5ND) 患者中研究大脑网络拓.
- 在CKD 5ND中分析结构功能合.
- 将大脑网络的变化与认知表现相关联.
主要方法:
- 扩散张力和静止状态功能性MRI用于40名CKD 5ND患者和47名健康对照.
- 图形理论分析评估了结构连接性 (SC) 和功能连接性 (FC) 的特性.
- 分析了结构功能合和蒙特利尔认知评估 (MoCA) 的得分.
主要成果:
- 与对照组相比,CKD 5ND患者的SC和FC网络属性显著改变,包括小世界性,效率和路径长度的变化.
- 在CKD 5ND患者中观察到高的SC-SC合.
- 网络参数与MoCA得分正相关,而路径长度与MoCA得分负相关.
结论:
- 患有CKD 5ND的患者显示大脑网络拓和结构功能合的显著变化.
- 这些网络变化与轻度认知障碍有关.
- 研究结果提供了关于CKD认知衰退的神经生物学基础的见解.
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