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炎症细胞透在周围假肢骨解中的作用

Isidora Panez-Toro^1,2,3, Dominique Heymann^2,3,4,5, François Gouin⁶

¹Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Chile, Independencia, Santiago, Chile.

Frontiers in immunology

|December 18, 2023

概括

这篇评论探讨了非骨髓单细胞细胞,如T细胞和B细胞,在骨科植入物的无菌松动. 这些细胞与巨细胞一起,有助于由磨损颗粒引起的周围假肢骨解.

科学领域:

整形外科手术整形外科手术
免疫学免疫学免疫学
生物材料科学生物材料科学

背景情况:

关节置换的无菌松动通常归因于颗粒诱导的周围假肢骨解.
这一过程涉及先天性和获得性免疫反应,导致骨质细胞激活和骨再吸收.
目前的理解表明外体慢性炎症由骨髓单细胞介导,但观察到异质炎症细胞.

研究的目的:

讨论非骨髓单细胞在暴露于磨损颗粒的周围假肢组织中的作用.
介绍各种免疫细胞透到回收的周围假肢膜中的原始数据.
阐明复杂的细胞和分子机制,这些机制是无菌松理论的基础.

主要方法:

关于粒子诱导的骨解和免疫反应的现有文献的审查.
从检索到的周围假肢膜中分析原始数据.
细胞群的免疫组合化学鉴定,包括T细胞 (CD3+,CD4+,CD8+),B细胞 (CD20+) 和多核巨细胞 (CD68+/TRAP-).

主要成果:

不同质的炎症细胞,除了髓单细胞衍生的细胞外,透到周围的假肢组织.
发现T细胞 (CD3+,CD4+,CD8+) 和B细胞 (CD20+) 与CD68+/TRAP多核巨细胞共存.
这些细胞透物与聚乙烯和金属磨损颗粒有关.

结论:

非骨髓单细胞在植入物-骨接口的炎症反应中发挥着重要作用.
与巨细胞一起存在的T细胞和B细胞有助于无菌松动的复杂病理.
本综述为推动骨科植入物失败的多面细胞和分子机制提供了宝贵的见解.

关键词:

无菌松是一种无菌松.这是一种炎症炎症炎症炎症.天生的免疫系统天生的免疫系统.巨细胞是一个巨细胞.骨质结晶体的骨质细胞.骨质免疫学骨质免疫学周围的假肢骨质溶解.整体关节更换整体关节更换

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