相关实验视频
Updated: Jul 8, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.7K
门德尔的随机化表明肠道失调和甲状腺癌之间存在因果关系
Feng Zhu1,2, Pengpeng Zhang3,4, Ying Liu5
1Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Frontiers in cellular and infection microbiology
|December 18, 2023
概括
这项研究使用了门德尔的随机化来研究肠道细菌和甲状腺癌 (TC) 之间的因果关系. 几种肠道微生物被确定为TC的风险因素或保护剂,这表明存在显著的关系.
科学领域:
- 微生物组研究的研究.
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
背景情况:
- 肠道微生物群的改变与甲状腺癌 (TC) 的发展有关.
- 肠道细菌和TC之间的确切因果关系尚不清楚.
研究的目的:
- 通过双向双样本孟德尔随机化 (TSMR) 分析,研究肠道微生物群和甲状腺癌之间的潜在因果关系.
- 确定与增加或减少甲状腺癌风险相关的特定微生物种群.
主要方法:
- 使用全基因组关联研究 (GWAS) 数据对肠道微生物群 (18,340个人) 和甲状腺癌 (6,699例,1,613,655例对照) 进行双向TSMR分析.
- 采用反变量加权 (IVW) 方法进行初级分析,加权中位数,加权模式,简单模式和MR-Egger作为补充方法.
- 通过使用Cochrane Q测试,MR-Egger拦截测试和MR-PRESSO全球测试来评估异质性和性. 进行反向TSMR分析以检查反向因果关系.
主要成果:
- 确定了七种与甲状腺癌风险相关的微生物种群.
- 种类 *Butyrivibrio*, *Fusicatenibacter*, *Oscillospira*, *Ruminococcus2* 和 *Terrisporobacter* 与TC风险的增加有关.
- * Olsenella * 和 * Ruminococcaceae UCG004 * 与降低TC风险有关. 反向MR分析没有证据表明反向因果关系.
结论:
- 这项研究表明,肠道微生物群在甲状腺癌发展中的潜在因果作用.
- 这些发现为肠道微生物群参与TC提供了新的见解.
- 需要进一步的研究来阐明潜在的生物机制.
相关概念视频
Mismatch Repair
4.9K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.9K
Irritable Bowel Syndrome I: Introduction
279
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
279
Anatomy of the Intestines
72.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.1K
Mutations
82.8K
Overview
82.8K
Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K
Chronic Bowel Disorders: Introduction
456
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
456

