年轻人的心血管和死亡风险健康查检查与边际估计的GFR
Minsang Kim1, Kyungdo Han2, Kwon Wook Joo1,3,4
1Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Kidney international reports
|December 18, 2023
概括
边缘功能 (eGFR 60-75) 在年轻人中没有增加死亡率或心血管风险. 对这些估计的膜过率值的进一步调查对于这个人群可能不需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 在年轻成年人中解释功能,特别是在边际估计膜过率 (eGFR) 值的情况下,需要进一步的证据.
- 对于临床实践来说,了解eGFR与这一人口群体的不良健康结果之间的关联至关重要.
研究的目的:
- 在年轻成年人中,研究估计的膜过率 (eGFR) 和不良结果之间的关联,包括所有原因的死亡率和主要不良心血管事件 (MACE).
- 为了确定边际EGFR水平是否在一般年轻成年人群中构成重大风险.
主要方法:
- 一项全国性的回顾性队列研究使用韩国健康查数据库进行.
- 包括3,132,409名年轻成年人 (20-39岁) 没有先前的MACE或功能衰竭,在2012年进行了查.
- 考克斯回归分析被用来评估所有原因死亡率和MACE的风险,eGFR被分类为15毫升/分钟/1.73米2的间隔.
主要成果:
- 边际eGFR (60-75毫升/分钟/1.73米2) 与年轻成年人所有原因死亡率 (aHR 0.80) 或MACE (aHR 0.94) 的增加没有显著关联.
- 专尿显示与eGFR和死亡风险有显著的相互作用 (P=0.028),但对于那些患有专尿和边际eGFR的人来说,风险仍然不显著.
- 随访时间的中位数为7.3年.
结论:
- 边际eGFR水平 (60-75毫升/分钟/1.73米2) 与一般年轻成年人群中因任何原因死亡或MACE的风险较高无关.
- 在年轻人中偶尔检测到的边际EGFR值的常规临床检查可能是不必要的.
- 这项研究提供了指导临床决策的证据,以评估年轻人的功能.
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