锡比宁对认知障碍的影响:希望还是治疗?
Zahra Akhoond-Ali1,2, Alireza Rahimi3, Atiyeh Ghorbani4
1Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Avicenna journal of phytomedicine
|December 18, 2023
概括
一种植物化合物西利比宁通过减少神经炎症和氧化应激减轻认知障碍,有望改善认知障碍. 它影响关键的大脑路径和蛋白质,为认知能力下降提供治疗潜力.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 神经炎症,氧化应激和神经元死亡是神经系统疾病和认知障碍的核心.
- 包括西利比宁在内的植物化合物正在因其神经保护和认知增强特性而受到研究.
研究的目的:
- 审查实验证据,对机理,其中silibinin影响认知障碍.
- 探索西利比宁作为治疗认知障碍的治疗剂的潜力.
主要方法:
- 从2000年到2021年,在主要的科学数据库 (ISI,谷歌学者,Scopus,Medline,PubMed) 中进行了全面的文献搜索.
- 相关的文章被识别使用关键词与silibinin和认知障碍相关.
主要成果:
- 西利比宁通过多种途径缓解认知衰退,包括减少神经炎症和氧化应激.
- 它调节ROS-BDNF-TrkB通路,增加树突棘,并抑制高酸化.
- 西利比宁会影响神经递质比率 (HVA/DA,DOPAC+HVA/DA,5-HIAA/5-HT) 和受体表达 (IR,IGF-1R).
结论:
- 锡利比宁显示出作为一种治疗剂的显著潜力,可以减少认知障碍症状.
- 它的多方面的作用包括调节炎症,编程细胞死亡和大脑中的氧化应激.
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