评估流感病例定义,用于现实世界的证据研究
Pamela Doyon-Plourde1,2, Élise Fortin1,3, Caroline Quach1,2,4,5
1Department of Microbiology, Infectious Diseases, and Immunology, Faculty of Medicine, University of Montréal, Montréal, QC.
概括
医疗保健行政数据可以使用特定的诊断代码准确追踪流感发病率. 这种方法对于在没有实验室确认的情况下进行疫苗有效性研究至关重要,确保可靠的公共卫生监测.
科学领域:
- 流行病学 流行病学
- 公共卫生监督 公共卫生监督
- 医疗信息学 医疗信息学
背景情况:
- 实验室确认流感不是标准的做法.
- 医疗保健行政数据库为流感疫苗有效性研究提供了潜力.
- 在这些数据库中经常使用临床诊断代码.
研究的目的:
- 将从临床诊断码中得出的流感发病率曲线与美国疾病控制和预防中心 (CDC) 的监测数据进行比较.
- 评估行政数据对流感监测的有用性.
主要方法:
- 使用病例序列方法,分析疾病预防控制中心周的流感发病率.
- 国际疾病分类的诊断代码定义了四个季节 (2015-2019) 的流感病例.
- 数据与CDC对实验室确认的流感和类似流感的监测数据进行了比较.
主要成果:
- 使用诊断码的医疗接触的发病率曲线与实验室证实流感的CDC数据密切相匹配.
- 与流感类似的疾病发生的情况显示出差异,在早期循环期间高.
- 这表明诊断代码提供了一个更符合确诊病例的措施.
结论:
- 当没有实验室确认的流感数据时,优先考虑特定病例定义.
- 更广泛的病例定义可能会在流感疫苗有效性研究中引入保守偏见.
- 有了适当的定义,行政数据可以成为流感监测的宝贵工具.
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