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固体瘤免疫治疗的微生理系统:机遇和挑战

Sara Abizanda-Campo^1,2,3,4,5,6, María Virumbrales-Muñoz^2,7, Mouhita Humayun⁸

¹Department of Dermatology, University of Wisconsin-Madison, Madison, WI USA.

Microsystems & nanoengineering

|December 18, 2023

概括

免疫疗法在固体瘤中面临挑战,原因是免疫抑制的微环境. 微生理系统 (MPS) 提供了一种有希望的方法来研究和克服这些障碍,以有效治疗癌症.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

免疫疗法对血液瘤比固体瘤更有效.
固体瘤产生免疫抑制的微环境 (低氧,酸性pH,废物积累),阻碍免疫细胞,如细胞毒性T细胞和自然杀手细胞.
瘤透细胞 (纤维细胞,巨细胞,T调节细胞) 进一步抑制抗瘤免疫力,并促进免疫逃避.

研究的目的:

审查研究瘤微环境和免疫瘤学的微生理系统 (MPS).
突出MPS在评估固体瘤新型免疫疗法的潜力.
讨论利用MPS用于癌症免疫疗法研究的挑战和机会.

主要方法:

对免疫瘤学的微生理学平台的现有文献的审查.
分析微流体设备如何重复瘤复杂性的分析.
讨论在解读免疫细胞与瘤相互作用和评估免疫疗法的应用.

主要成果:

微生理系统 (MPS) 正在成为模拟复杂瘤微环境的多功能工具.
在固体瘤中,MPS可以帮助阐明免疫细胞细胞毒性,疲劳和排斥的机制.
免疫疗法评估中MPS的具体例子仍然有限,但显示出显著的潜力.

结论:

微生理系统 (MPSs) 对推进固体瘤免疫疗法研究具有前景.
进一步开发和应用MPS对于克服瘤免疫逃避至关重要.
免疫疗法可以加速新免疫疗法策略的开发和评估.

关键词:

工程工程师工程师工程师纳米流体的使用方法

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Tumor Immunotherapy

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