一项回顾性观察性研究,对比了COVID后粘性菌根症的不同诊断方式
Guddi Rani Singh1, Shabana Azad2, Mamta Kumari1
1Pathology, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Cureus
|December 18, 2023
概括
组织病理学和KOH安装是黑色真菌 (粘菌菌) 的经济有效的诊断工具. 组织病理学提供100%的灵敏度和特异性,而KOH安装在诊断这种严重的真菌感染时显示88.3%的灵敏度.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 诊断病理学的诊断病理学
背景情况:
- 粘真菌菌或黑色真菌是一种罕见但危及生命的真菌感染,由粘真菌菌引起.
- 虽然在COVID-19大流行期间它的发病率增加了,但粘性菌在大流行前是一个重大问题.
- 了解COVID前的流行情况为大流行时代的影响和动态提供了背景.
研究的目的:
- 为了确定各种诊断方法的敏感性,用于粘膜菌.
- 为了比较微生物学与体病学诊断的有效性.
- 分析不同诊断方法的成本效益.
主要方法:
- 追溯性观察性研究,对77例通过组织病理学检查 (HPE) 诊断的粘性菌病例进行了观察.
- 包括在HPE之前进行的微生物学测试 (KOH安装,真菌培养,MALDI-TOF MS).
- 对敏感度,特异性和千平方测试进行统计分析,用于诊断比较.
主要成果:
- 组织病理学诊断 (PAS和GMS染色) 显示了100%的灵敏度和特异性.
- KOH安装灵敏度为88.3%;真菌培养和MALDI-TOFMS灵敏度为75.3%.
- 在55%的病例中观察到绝对的中性恋;在58%的病例中,组织病理学显示了丰富的真菌菌.
结论:
- 组织病理学和KOH安装是对粘膜菌的富有同情心和具有成本效益的诊断工具.
- MALDI-TOF MS是快速确认真菌亚型的可行方法.
- 绝对中性嗜好在55%的粘膜性菌病例中是一致的发现.
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