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微RNA中的四种常见多态化与肝细胞癌风险之间的关联:最新的元分析

Mingxing Chen¹, Yu Lu², Xinyang Wang¹

¹Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.

Iranian journal of public health

|December 18, 2023

概括

这次元分析发现,微RNA149 (MIR149) 和微RNA196 (MIR196) 多态性是预防肝细胞癌 (HCC) 的保护因素. 这些发现表明,与这些特定的microRNA遗传变异相关的HCC发病风险降低.

科学领域:

遗传学遗传学是一个
在瘤学瘤学.
流行病学流行病学

背景情况:

对单核酸多态和肝细胞癌 (HCC) 的流行病学研究产生了有争议的结果.
需要进行全面的元分析,以更精确地估计微RNA (MIR) 多态性和HCC风险之间的关联.

研究的目的:

进行大规模的元分析,以澄清微RNA多态和肝细胞癌 (HCC) 风险之间的关联.

主要方法:

在多个数据库 (PubMed,Cochrane Library,Google Scholar,Web of Science,EMBASE,CBM) 进行了系统的文献搜索,截至2021年9月30日.
包括的研究研究了MIR多态和HCC风险之间的关联.
使用几率比率 (OR) 和95%置信区间 (CI) 来评估相关性.

主要成果:

分析包括29项研究,包括9263例病例和10875例对照.
微RNA149 (MIR149) 多态性在整体人群中显著降低了HCC风险 (同卵性模型CC与TT:OR = 0.703,P = 0.005).
微RNA 196 (MIR196) 多态性显著降低了整体人群中的HCC风险 (递归模型TT与CT+CC:OR = 0.864,P = 0.04) 和白人 (OR = 0.613,P = 0.014).

结论:

MIR149和MIR196多态是防止HCC发展的保护因素.
未来的研究应该考虑多中心,多区域的研究,包括基因-基因和基因-环境相互作用.

关键词:

肝细胞癌是肝细胞癌.进行元分析分析.这是一个微型RNA.多态性多态性多态性易感性易感性易感性

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