系统性免疫炎症指数增加与2型糖尿病外周神经病变有关:中国人口的跨部门研究
Jia Li1,2,3,4,5, Xing Zhang1,2,3,4,5, Yi Zhang1,2,3,4,5
1Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Journal of inflammation research
|December 18, 2023
概括
系统性免疫炎症指数 (SII) 与中国成年人患糖尿病外围神经病 (DPN) 的风险更高有关. 这种炎症标志物可能成为识别DPN风险的新生物标志物.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 系统性免疫炎症指数 (SII) 是一种与2型糖尿病 (T2DM) 和其血管并发症相关的新兴炎症标志物.
- 之前没有报道过SII和糖尿病外围神经病变 (DPN) 之间的关系.
研究的目的:
- 调查SII与中国2型糖尿病人群中DPN患病率之间的关联.
主要方法:
- 一项涉及1460名住院T2DM患者的横截面研究.
- SII计算为血小板计数 × 中性粒细胞计数/淋巴细胞计数.
- 使用相关性,多变量逻辑回归和子组分析来评估SII和DPN之间的关联.
主要成果:
- 较高的SII四分位数与振动感知值和DPN流行率的增加显著相关 (P<0.01).
- SII是DPN患病率的独立正预测指标 (P<0.01),最高四分位数显示显著增加的风险 (OR:1.211,P<0.05).
- 在特定的子组中观察到积极的关联,包括男性,65岁以下的个人,BMI <24 kg/m2,糖尿病持续时间 >5年,高血压,失脂症,血糖控制差,和eGFR <90 mL/min/1.73 m2.
结论:
- 升高的SII独立地与中国人口中增加的DPN风险有关.
- 在T2DM患者中,SII可能代表DPN的新型风险生物标志物.
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