探索神经退行性疾病的连接:微质作为中心
Yan Wang1,2,3,4, Limei Cui2,3,4, He Zhao1,2,3,4
1The Second Medical College, Binzhou Medical University, Yantai, Shandong, People's Republic of China.
Journal of inflammation research
|December 18, 2023
概括
减少微质细胞活动可以制退行性疾病. 这篇评论探讨了微质细胞.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 退行性疾病带来了重大的健康和社会挑战.
- 中枢神经系统的免疫细胞微质细胞在疾病的发病过程中起着至关重要的作用.
- 了解微质细胞机制是开发有效治疗方法的关键.
研究的目的:
- 审查各种退行性疾病中微质细胞的机制.
- 检查微细胞抑制剂和激活剂的影响.
- 突出微质在炎症和疾病进展中的双重作用.
主要方法:
- 关于神经退行性疾病,与年龄相关的听力损失,阿尔茨海默病,帕金森病和外周神经系统疾病中的微质研究的文献综述.
- 对微细胞调节剂 (如PLX3397/PLX5622和脂多糖) 的研究分析.
主要成果:
- 微质细胞与各种退行性疾病的发病有关.
- 抑制微质细胞 (例如,与PLX3397 / PLX5622) 显示出抑制疾病起源和进展的潜力.
- 微质表现出抗炎和促炎功能,在中央和外围疾病中至关重要.
结论:
- 调节微质活动,特别是减少它们的有害影响,为退行性疾病提供了一个有前途的治疗策略.
- 准微质细胞为未来的治疗提供了一个可行的途径,尽管它们的复杂性质.
相关概念视频
01:04Glial Cells
87.3K
Overview
87.3K
01:31Nervous Tissue: Glial Cells
3.0K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
3.0K
01:15Neurogenesis and Regeneration of Nervous Tissue
824
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
824