在主观记忆障碍中,金素丰富分量的认知功能改善效应:评估者和参与者盲目的安慰剂对照研究
Rami Lee1, Han Sang Lee2, Won-Woo Kim1
1Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Journal of ginseng research
|December 18, 2023
概括
富含丁的基因组 (GEF) 改善了主观记忆障碍患者的认知功能,在K-ADAS和K-SCWT得分上显著提高. 这种来自人参的化合物对于轻度认知障碍是安全有效的.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
背景情况:
- 人参衍生的 lysophosphatidic acid (LPA) 受体连接体 - - 丁在临床前阿尔茨海默病模型中显示出有前途的结果.
- 在动物研究中,用银色素丰富分数 (GEF) 证明了粉样质斑块的抑制和认知功能的改善.
- GEF促进海马神经发生并增加乙胆水平,这表明对认知衰退的潜在治疗益处.
研究的目的:
- 评估在主观记忆障碍 (SMI) 患者中使用金素丰富分数 (GEF) 的疗效和安全性.
- 通过使用标准化认知测试来评估GEF对认知表现的影响.
- 确定GEF的最佳剂量,以改善SMI患者的认知功能.
主要方法:
- 一项为期八周的随机化,安慰剂控制的研究,涉及136名SMI参与者.
- 参与者被分配接受安慰剂,每天300毫克GEF或每天600毫克GEF.
- 认知功能使用韩国版本的阿尔茨海默病评估量表 (K-ADAS),迷你精神状态检查 (K-MMSE) 和Stroop色词测试 (K-SCWT) 来评估.
主要成果:
- 与安慰剂组相比,在GEF组的K-ADAS和K-SCWT得分中观察到显著的改善.
- 在GEF和安慰剂组之间,K-MMSE或BDI得分没有显著改善.
- 在为期八周的研究期间,在GEF或安慰剂组中没有报告任何不良事件.
结论:
- 基因丰富分数 (GEF) 对于改善认知障碍的特定方面是安全有效的,正如K-ADAS和K-SCWT结果所示.
- GEF显示出作为主观记忆障碍治疗剂的潜力.
- 建议进行进一步的大规模随机对照研究,以证实研究结果并探索更广泛的认知益处.
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