皮和骨关节炎的研究
Shuangshuo Jia1, Ziyao Yu2, Lunhao Bai1
1Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
Frontiers in physiology
|December 18, 2023
概括
运动所分泌的称为exerkines的蛋白质在骨关节炎 (OA) 管理中起着双重作用. 一些运动激素提供治疗益处,而另一些则可能使病情恶化,影响关节细胞.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 运动生理学 运动生理学
背景情况:
- 骨关节炎 (OA) 是一种普遍存在的关节疾病,可以通过体育炼来控制.
- 运动激素是运动期间释放的细胞因子,通过内分泌,副分泌或自身分泌路径起作用.
- 组织特异性的运动激素,如肌动素,心动素和脂肪素,都与OA运动治疗有关.
研究的目的:
- 审查组织特异性肌肉在骨关节炎中的作用.
- 探索OA中exerkine作用的细胞和分子机制.
- 突出调节OA中的exerkine效应的治疗潜力.
主要方法:
- 关于肌和OA最近发现的文献综述.
- 分析参与exerkine作用的细胞和分子机制.
- 基于其在OA中的治疗性或有害作用而对exerkines进行分类.
主要成果:
- 在OA中鉴定了有益的エク瑟基因 (例如,虹膜素,阿迪波内克丁) 和有害的エク瑟基因 (例如,IL-6,GDF-15).
- 埃克斯基因会影响子细胞,子细胞和介质干细胞,影响亡,热亡,炎症,生和衰老.
- 阿迪波基因通过对关节内细胞的调节对OA干预具有特别的希望.
结论:
- 组织特异性的肌肉激素显著影响骨关节炎.
- 了解exerkine机制为OA提供了新的治疗策略.
- 针对exerkine通路,特别是adipokines,为OA干预提供了一个有希望的未来.
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