在帕金森病中表征神经认知障碍,使用移动EEG在走路和跨越障碍物时
Magda Mustile1,2, Dimitrios Kourtis1, Martin G Edwards2
1Psychology, Faculty of Natural Sciences, University of Stirling, Stirling, FK9 4LA, UK.
Brain communications
|December 18, 2023
概括
帕金森病患者在避开障碍物时表现出大脑活动受损,影响了主动和反应性运动控制. 这项研究揭示了日常行走挑战中运动认知缺陷的神经标志物.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 认知神经科学 认知神经科学
背景情况:
- 帕金森病 (PD) 患者面临着在环境中导航的重大挑战,导致跌倒和住院.
- 传统的神经成像方法由于静止要求,限制了对运动障碍的理解.
- 动物模型经常被使用,但理解现实世界的挑战需要人类研究.
研究的目的:
- 研究帕金森病患者在自然步行过程中避开障碍物的神经相关性.
- 为了确定与PD中主动和反应性步态调整相关的大脑活动模式.
- 探索预期与意想不到的障碍对PD行走的认知控制的影响.
主要方法:
- 利用移动电脑电图 (EEG) 来记录14名服用药物治疗的PD患者和17名对照者的大脑活动.
- 参与者自由行走,跨越预期和意想不到的障碍.
- 在 (4-7 Hz) 和β (13-35 Hz) 频段分析了EEG数据.
主要成果:
- 与对照组相比,帕金森病患者在和β频段显示皮质活动减少.
- 通过减少对意想不到的障碍物调整而增加的Theta功率来表明主动控制受损.
- 降低β功率抑制和减弱的β反弹信号表明行动计划和反应控制中的缺陷.
结论:
- 帕金森病与在障碍物谈判期间控制步伐的普遍运动认知缺陷有关.
- 患者在避免障碍时表现出主动规划和反应性调整方面的障碍.
- 移动EEG识别了神经标记物,反映了在PD中避免障碍之前和之后适应运动的困难.
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