由于多发性硬化病变造成的区域结构性脱节的序列
Ceren Tozlu1, Emily Olafson1, Keith W Jamison1
1Department of Radiology, Weill Cornell Medicine, NewYork, NY, 10065, USA.
Brain communications
|December 18, 2023
概括
多发性硬化症 (MS) 大脑网络中的结构性断开,特别是像质体这样的皮质下区域,预测了残疾和认知衰退. 运动区域的偏磁边缘病变表明MS患者患有严重残疾的风险增加.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- 多发性硬化症 (MS) 疾病的进展是很难预测的,因为异质的病变发展和炎症.
- 了解与病变相关的结构性断开连接的序列对于预测MS中残疾和认知障碍至关重要.
研究的目的:
- 调查多发性硬化症 (MS) 的残疾和认知障碍的全谱中与病变相关的区域结构性断开连接的序列.
- 确定MS患者残疾进展和认知衰退的早期生物标志物.
主要方法:
- 分析了482名多发性硬化患者的队列,根据残疾 (扩展残疾状况表) 和认知状况 (简要国际认知评估) 进行分类.
- 定量敏感性映射确定了对磁边缘病变 (PRLs).
- 网络修改工具估计了区域结构性断开连接,基于事件的歧视性建模分析了损伤相关的断开连接序列.
主要成果:
- 腹部注意力和皮下网络 (上边缘,皮) 的结构性断开是中度至重度残疾的早期生物标志物.
- 由于运动区域的磁性边缘损伤造成的结构性断开是残疾进展的最早生物标志物.
- 皮下结构断裂 (腹腔二脑,大脑层) 是认知障碍的早期生物标志物.
结论:
- 皮层下区域的结构性断裂,特别是质体,是MS中残疾和认知障碍的早期生物标志物.
- 运动皮质中与偏磁边缘病变相关的结构性断开可能会确定患有严重残疾风险的多发性硬化患者.
- 这些发现可以帮助为患有进展或认知衰退风险的多发性硬化症患者制定个性化治疗计划.
相关概念视频
01:20Anatomy of the Brain: Major Regions
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:25Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...