利用认知轨迹集群来检查亚临床衰退风险因素
Lianlian Du1,2,3, Bruce P Hermann1,4, Erin M Jonaitis1,2,3
1Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53792, USA.
Brain communications
|December 18, 2023
概括
轻微的认知能力下降在痴呆症之前,急剧下降与健康状况恶化和阿尔茨海默病生物标志物有关. 识别这些临床前模式有助于对认知障碍的早期干预.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 生物标志物 生物标志物
背景情况:
- 像阿尔茨海默氏症这样的痴呆症的认知衰退通常在症状明显之前就开始了.
- 早期识别亚临床认知衰退对于及时干预至关重要.
- 纵向研究对于了解老年人群的认知轨迹至关重要.
研究的目的:
- 在认知无障碍的成年人中识别不同的认知轨迹集群.
- 检查这些认知集群与基线/最近的健康特征,认知状态和阿尔茨海默病/血管生物标志物之间的关联.
- 解释老年成年人认知表现的异质性.
主要方法:
- 利用贝叶斯曲线回归来模拟来自1068名参与者的临床前阿尔茨海默病认知复合物的认知轨迹.
- 雇佣的K-意味着集群,以基于变化点和斜率来定义组.
- 在集群中分析了人口,临床和生物标记数据 (粉样蛋白,,神经退行,白质超强度,血pTau217).
主要成果:
- 确定了三个认知轨迹组:急剧 (7.2%),中等 (41.8%) 和最小 (51.0%) 的下降.
- 急剧下降的群体是年长的,更有可能是女性,携带APOE e4,并在最后一次访问时显示出较高的轻度认知障碍/痴呆率.
- 急剧下降与健康状况不佳,血管风险因素增加以及粉样蛋白,蛋白,神经退行症和白质强度过高的积极性有关.
结论:
- 在中年后期的成年人中存在明显的临床前认知轨迹.
- 认知轨迹与潜在的阿尔茨海默氏症和血管病理有关.
- 了解这些模式可以阐明认知异质性,并为痴呆症的早期检测策略提供信息.
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