大型变种的流行率和特征
Francesca Burlo1, Beatrice Lorenzon1, Gianluca Tamaro2
1Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Frontiers in endocrinology
|December 18, 2023
概括
女孩的thelarche变体 (TV) 呈现了过早的thelarche和中心早期青春期之间的中间阶段,以FSH占主导地位为特征. 近一半的电视病例进展到中部早期青春期,表明潜在的"早期青春期前"阶段.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖医学 生殖医学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 女孩早期的乳头发可呈现各种疾病,包括孤立的早发乳头发 (PT) 和中央早发性青春期 (CPP).
- 一个明显的中间临床图像,称为"thelarche变体" (TV),以FSH主导的反应为特征,但缺乏一致的定义.
研究的目的:
- 定义thelarche变种 (TV) 的临床,实验室和成像特征.
- 调查电视的进展到中部早期青春期 (CPP).
主要方法:
- 追溯分析91名患有早期大的女孩 (8岁以下) 接受LHRH测试.
- 分类为CPP (LH峰值≥5IU/L),TV (FSH峰值≥20IU/L,LH峰值<5IU/L) 和PT (FSH峰值<20IU/L,LH峰值<5IU/L).
主要成果:
- 电视患者较年轻,骨年龄较晚,基底和峰值FSH比较高,LH/FSH比较低.
- 卵巢毛囊>5毫米在TV中比PT更为普遍 (42%),尽管卵巢体积较小.
- 44%的TV病例进展为CPP,而PT病例则为14%;进展与更高的基线FSH和LH峰值有关.
结论:
- Thelarche变种的特点是FSH占主导地位,骨年龄较晚,以及特定的卵巢发现.
- 电视可能代表"早熟的青春期前期"状态,FSH优势可以延迟或最终触发青春期.
- 在电视上向CPP的进展与初步评估时的特定荷尔蒙特征有关.
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