肠道透性与严重的炎症和肌纤维细胞积累有关于Graves的轨道病:MicroGO的研究
Aline C Fenneman1,2, Anne H van der Spek2, Annick Hartstra1
1Department of (Experimental) Vascular Medicine, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centre (UMC), University of Amsterdam, Amsterdam, Netherlands.
Frontiers in endocrinology
|December 18, 2023
概括
格雷夫斯轨道病患者的肠道透性增加,允许细菌化合物恶化轨道炎症和纤维化. 这种肠眼轴的联系表明了潜在的微生物群向格雷夫斯病的治疗方法.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 格雷夫斯病和轨道病是由自身抗体对TSH受体的刺激引起的.
- 格雷夫斯轨道病的轨道组织扩张与局部细胞上的TSH受体表达有关.
- 在格雷夫氏病/轨道病患者中观察到肠道微生物组的干扰和肠道透性的增加.
研究的目的:
- 为了研究一种假设,即增强肠道透性加剧了Graves轨道病的轨道炎症.
- 探索肠道透性,轨道炎症和肌纤维细胞分化之间的联系.
主要方法:
- 研究了两组Graves轨道病患者,收集血液,便和轨道组织样本.
- 通过血清标记物 (LBP,zonulin) 和肠道细菌配体 (TLR5,TLR9) 评估肠道透性.
- 量化了轨道组织中的免疫细胞透和肌纤维细胞活性;分析了转录的概况.
主要成果:
- 格雷夫斯轨道病患者的LBP血清水平明显高于对照组.
- 增加的LBP与增加的zonulin,TLR5和TLR9连接体相关,表明肠道透性增加.
- 增加的肠道透性与增强的免疫细胞透和轨道组织中的纤维细胞激活有关.
- 血清LBP水平与特定的肠道细菌相关,表明肠道轨道炎症联系.
结论:
- 格雷夫斯轨道病患者表现出增强的肠道透性,促进细菌转移.
- 转位的细菌化合物可能会加剧轨道炎症并促进肌纤维细胞激活,导致组织扩张.
- 这些发现支持探索肠道轨道轴和针对Graves轨道病的微生物向疗法.
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