在多发性硬化症中脑缩和身体和认知障碍
Luis Ignacio Casanova Peño1, Carlos López De Silanes De Miguel1, Laura de Torres1
1Department of Neurology, Torrejón University Hospital, Madrid, Spain.
Basic and clinical neuroscience
|December 18, 2023
概括
脑缩,以灰质体积和T2损伤负载来衡量,与多发性硬化症患者的身体残疾相关. 在这项研究中,认知功能与大脑体积没有显著联系.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 放射学 放射学是指放射学
背景情况:
- 脑缩是多发性硬化症 (MS) 身体残疾的已知相关因子,但其临床应用有限.
- 研究方法的变化阻碍了在临床实践中持续使用脑缩.
研究的目的:
- 在临床环境中分析大脑体积测量与MS患者身体残疾和认知功能之间的关系.
- 评估大脑缩测量在常规临床实践中监测MS进展的可行性.
主要方法:
- 横截面研究包括41名跨不同表型的多发性硬化患者.
- 使用Icometrix软件进行全脑体积 (WBV),灰质体积 (GMV) 和T2损伤负荷 (T2L) 的量化.
- 使用扩展残疾状态尺度 (EDSS) 评估身体残疾,使用神经心理测试简要可重复电池 (BRB-N) 评估认知功能.
主要成果:
- 灰质体积 (GMV) 与年龄和身体残疾 (EDSS) 有关.
- T2损伤负荷 (T2L) 与身体残疾 (EDSS) 有显著的关联.
- 认知障碍和大脑体积之间没有发现显著的相关性;然而,认知功能障碍在初级进展性MS表型中更为普遍.
结论:
- 脑缩测量,包括GMV和T2L,在临床环境中是可行的和有价值的,用于监测MS的身体残疾进展.
- 初级渐进性MS表型与认知功能障碍的风险增加有关.
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