查加夫的第二个平价规则在于,在定量特征中的附加性遗传相互作用的起源,使全基因选择成为可能
Bakhyt T Matkarimov1,2, Murat K Saparbaev3,4
1National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
PeerJ
|December 18, 2023
概括
查加夫的第二平价规则 (CSPR),或内链DNA对称性,解释了随机突变如何导致复杂特征的持续变化. 这种遗传变异服从CSPR,将其与费舍尔的无限小模型联系起来,并为遗传相互作用提供了新的见解.
科学领域:
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
- 进化生物学 进化生物学
背景情况:
- 弗朗西斯·克里克的中心教条解释了遗传信息流动,但可能无法完全解释随机突变导致复杂特征的持续变异.
- 查加夫的第二平价规则 (CSPR) 或DNA链内对称性,描述了DNA链内近等的基对数量 (G≈C,A≈T),这是一个基因组属性,具有不清楚的生物学作用.
- 这项研究调查了DNA内部对称性和遗传相互作用在定量特征的起源之间的潜在联系.
研究的目的:
- 探索DNA内部对称性 (CSPR) 与遗传相互作用在定量特征中的出现之间的关系.
- 为了确定随机遗传变异是否符合CSPR.
- 调查CSPR对进化理论和遗传变异的影响.
主要方法:
- 在人类和小鼠群体中单核酸多态 (SNP) 的计算分析.
- 分析细菌和人类蛋白质组中的不同编码子位置的核酸组成偏差.
主要成果:
- 来自人类和小鼠SNP的突变光谱显示了几乎相同数量的反向互补突变,支持随机遗传变异遵循CSPR.
- 编码序列中的核酸组合通过CSPR统计交织在一起,在第3个编码子位置有pyrimidine偏差,在第1和第2个位置平衡purin偏差.
结论:
- 由CSPR指导的反向互补突变,通过微小的添加效应导致持续的表型变异,正如费舍尔无限小的模型所建议的那样.
- 添加基因相互作用可以被视为跨基因位置的核酸组成的统计纠.
- 通过涉及特征变异的所有随机突变,CSPR挑战了中性进化理论,并通过扩散基因功能来解决哈尔丹的困境,这表明隐含的遗传信息传输.
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