在患有慢性阻塞性肺部疾病的受试者中,脆弱是死亡率预测因素吗?
Koichi Nishimura1,2, Masaaki Kusunose3, Ayumi Shibayama4
1National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
慢性阻塞性肺病 (COPD) 患者的虚弱与较高的死亡率有关. 虽然脆弱性预测死亡率,但与空气流量限制 (FEV1) 相比,其预测能力仍然不确定.
科学领域:
- 老年学是一门学科.
- 肺部病理学 肺部病理学
- 临床医学 临床医学
背景情况:
- 慢性阻塞性肺病 (COPD) 经常与脆弱性有关.
- 需要进一步阐明COPD患者的脆弱性和死亡率之间的关系.
- 关于虚弱或空气流量限制是否是COPD死亡率更强的预测因素存在争议.
研究的目的:
- 调查COPD稳定患者的脆弱性和死亡率之间的联系.
- 为了比较虚弱状态与空气流量限制 (FEV1) 的预测值,用于COPD患者的死亡率.
主要方法:
- 141名稳定的COPD患者接受了肺功能测试和Kihon检查清单评估.
- 根据Kihon检查清单得分,患者被分为强壮,前脆弱和脆弱的组.
- 对死亡率的随访数据收集时间长达95个月.
主要成果:
- 20.5%的参与者 (29/141) 在随访期间死亡.
- 与强壮患者相比,脆弱的COPD患者的死亡率明显高 (p=0.004单变量,p=0.024多变量).
- 虚弱和空气流量限制显示出类似的死亡率预测能力 (C指数为0.63-0.66).
结论:
- 虚弱是COPD患者死亡率的重要预测因素.
- 脆弱的COPD个体的死亡风险比强壮个体高.
- 需要进一步的研究,以确定脆弱性或FEV1是否是COPD死亡率的优越预测因素.
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