在帕金森病的认知训练的长期影响:一个随机的,受控的试验
Tim D van Balkom1,2,3, Odile A van den Heuvel1,2,3,4, Henk W Berendse5,3
1Amsterdam UMC, Vrije Universiteit Amsterdam, Psychiatry, De Boelelaan 1117, Amsterdam, The Netherlands.
Clinical parkinsonism & related disorders
|December 18, 2023
概括
对帕金森病的计算机认知训练没有显示长达两年的持续认知益处. 需要进一步的研究来开发有效的,长期治疗帕金森病的认知障碍.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 计算机化认知训练显示了改善帕金森病认知障碍的潜力.
- 在帕金森病中认知训练的长期影响的证据是有限的.
- 这项研究旨在评估认知训练效应在干预后长达两年的持久性.
研究的目的:
- 为了评估一项为期八周的计算机认知训练计划的长期耐用性.
- 在干预后长达两年的帕金森病患者中评估认知功能,精神状态和运动症状.
- 为了确定认知训练是否会影响帕金森病中认知状态的转换.
主要方法:
- 一个双盲随机受控试验,涉及136名患有帕金森病和主观认知投诉的人.
- 参与者接受了计算机认知训练 (BrainGymmer) 或为期八周的积极对照.
- 神经心理评估,精神病学问卷和运动症状评估在基线,一年和两年进行.
主要成果:
- 在1年和2年的随访中,没有观察到神经心理结果的显著群体差异.
- 认知状态转换的可能性在认知训练和对照组之间是相似的.
- 随访期间错过了大量的评估,部分原因是COVID-19的限制.
结论:
- 一个为期八周的计算机认知训练计划在帕金森病中没有产生显著的长期认知益处.
- 未来的研究可以从专注于特定的认知子组中获益,以提高研究可靠性.
- 改善干预设计是必要的,以实现有效和持久的治疗选择,在帕金森病的认知衰退.
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