在患有或没有胰岛素抵抗的糖尿病患者中对抗氧化剂状况的比较分析
Suad Lateef Ibrahim1, Nadia Khadam Jawad Al-Dawah2, Muna Abdulridha Al-Barqaawi3
1Department of Clinical Laboratory Sciences, Faculty of Pharmacy, University of Kufa, Kufa, Iraq.
患有胰岛素抵抗的糖尿病患者表现出氧化应激标志物增加,如甲 (MDA) 和尿酸,并减少了谷氨 (GSH). 这些变化与血糖控制不良和脂质失调相关.
科学领域:
- 生物化学 生物化学
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 糖尿病 (DM) 与胰岛素抵抗和高血糖症有关.
- 过高血糖可能会诱导氧化应激,损害胰岛素功能.
- 氧化应激与胰岛素耐药性和脂质失调症的发展有关.
研究的目的:
- 为了比较胰岛素抵抗和不抗胰岛素的糖尿病患者的麦隆迪阿尔海德 (MDA),谷氨 (GSH) 和尿酸水平.
- 评估这些标记物,禁食血糖 (FBS) 和脂质资料之间的相关性.
主要方法:
- 对MDA,GSH和尿酸水平进行比较分析.
- 评估FBS,HbA1C,胰岛素活性,HOMA-IR和脂质样本 (总胆固醇,三甘油,HDL,VLDL,LDL-C) 的情况.
- 统计分析以确定显著差异和相关性.
主要成果:
- 胰岛素耐药和非耐药糖尿病组之间MDA,尿酸和GSH水平的显著差异 (p<0.0001).
- 胰岛素抵抗组的FBS,HbA1C,胰岛素活性,HOMA-IR和所有测量脂质参数的升高 (p<0.0001).
- 在尿酸和LDL-C之间发现了显著的相关性 (p<0.01),在HDL-C和MDA/尿酸之间发现了负相关性 (p<0.001).
结论:
- 降低GSH和增加MDA和尿酸水平是糖尿病患者胰岛素抵抗的特征.
- 氧化应激标志物在患有胰岛素抵抗的糖尿病患者中显著改变.
- 研究结果表明,氧化应激在胰岛素耐药性和糖尿病相关脂质不良症的发病过程中起着作用.
更多相关视频
06:13Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
