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相关概念视频

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Author Spotlight: Exploring the Impact of Lingnan Fire-Needle Therapy in Osteoporosis Intervention
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在骨质疏松症的顺序治疗.

Ravi Sauhta1, Dheeraj Makkar2, Pooja Sauhta Siwach3

  • 1Department Orthopedics and Joint Replacement, Artemis Hospitals, Gurgaon, India.

Indian journal of orthopaedics
|December 18, 2023
PubMed
概括

优化骨质疏松症治疗包括连续的药物治疗. 开始使用合成代谢剂,然后用抗吸收剂,比其他序列更有效地改善骨质.

关键词:
阿巴洛帕拉蒂德 (Abaloparatide) 是一种类型.双酸盐 (BPN) 是一种双酸盐.组合疗法是一种联合疗法.德诺苏玛布 (Dmab) 是一种药物.骨折 骨折 骨折 骨折 是一种脆弱性骨折是一种脆弱性骨折.骨质疏松症是一种骨质疏松症.罗马索祖马布 (Romosozumab) 是一种药物.查检查 查检查 查检查测序治疗方法的测序.序列疗法是一种序列疗法.泰里巴拉提德 (TPTD) 是一种过渡期疗法是一种过渡期疗法.没有得到充分的治疗.

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科学领域:

  • 内分泌学 在内分泌学.
  • 药理学 药理学是指药理学的学科.
  • 骨生物学 骨生物学 骨生物学

背景情况:

  • 骨质疏松症的管理经常采用顺序治疗策略.
  • 这些策略是基于患者因素,治疗反应和骨折风险的个性化.

研究的目的:

  • 为了评估连续抗骨质疏松症药物治疗的有效性.
  • 为了确定长期骨质疏松症管理的最佳药物测序.

主要方法:

  • 对PubMed和EMBASE数据库 (1995-2023) 的系统文献综述.
  • 对顺序性骨质疏松症药物治疗的原始文章和临床试验的分析.
  • 检查药物机制,副作用和治疗趋势.

主要成果:

  • 最佳的骨质改善是通过启动使用合成代谢剂的治疗,其次是抗吸收药.
  • 开始使用双酸盐可能会降低后续合成代谢治疗阶段的结果.
  • 由于潜在的骨周转问题,建议在从登苏马布转换为PTH类型时谨慎使用.

结论:

  • 序列治疗为骨质疏松症管理提供了一种灵活,定制的方法.
  • 优化测序可以提高骨折预防和患者的治疗结果.