相关实验视频
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Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
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在和后控制口腔微生物组的变化
Xiaolei Lian1,2, Zhenguo Liu3,4, Tianwen Wu1
1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in microbiology
|December 18, 2023
概括
口腔微生物组分析显示,患者与健康个体相比存在明显的差异. 这些发现表明,口腔微生物组可以作为的新型,非侵入性诊断工具.
科学领域:
- 微生物组研究的研究.
- 神经学 神经学
- 诊断创新是一种创新.
背景情况:
- 目前的诊断方法,如病史和EEG有局限性.
- 需要更可靠,更容易获得的诊断工具.
研究的目的:
- 描述患者 (EP) 和控制发作 (EPR) 的患者的口腔微生物群.
- 为了确定不同病状态的潜在口腔微生物生物标志物.
- 探索口腔微生物组作为的非侵入性诊断工具的潜力.
主要方法:
- 16S rRNA基因测序在480个舌头拭子上进行.
- 从157个EP,22个EPR和301个健康对照 (HC) 收集了样本.
主要成果:
- 与对照组相比,患者表现出口腔微生物群α多样性增加和β多样性显著差异.
- 在EP中,特定的细菌系显著增加 (例如,Streptococcus) 或减少 (例如,Peptostreptococcus).
- 口服微生物标记物在训练,验证和独立组的患者中实现了高准确性 (AUC>92%).
结论:
- 口腔微生物组在患者和健康个体之间存在显著差异.
- 在患者中观察到明显的口腔微生物特征,发作控制.
- 口腔微生物组作为的非侵入性诊断生物标志物具有前途.
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