基于基和异环组合的希夫基的合成:对抗菌活性的评估
M Ali1, Essam Nageh Sholkamy2, Ahmed S Alobaidi2
1Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
ACS omega
|December 18, 2023
概括
用热和超声波方法合成了基松希夫基,显示出增强的热稳定性和强大的抗菌活性. 超声合成的CSM4U显示出卓越的抗菌和抗真菌特性,性能优于Gentamicin和Terbinafine.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 抗菌研究 抗菌研究
背景情况:
- 酸盐 (CS) 是一种生物相容的聚合物,在各种领域都有潜在的应用.
- 修改素可以增强其特性,如热稳定性和生物活性.
- 希夫基形成是功能化聚合物的常见策略,如奇托.
研究的目的:
- 通过热和超声波方法,利用四种不同的异环化合物合成奇托桑希夫基.
- 描述合成的奇托桑希夫基,并评估它们的热稳定性.
- 评估准备的基酸盐 Schiff 基的抗微生物和抗真菌活性.
主要方法:
- 通过使用热和超声辐射与四种异环化物 (M1-M4) 反应生,合成生希夫基.
- 合成化合物的表征使用里埃变换红外光谱学 (FT-IR),X射线衍射 (XRD) 和热重力测量分析 (TGA).
- 评估抗微生物活性对抗格拉姆阳性和格拉姆阴性细菌和抗真菌活性对抗Candida物种.
主要成果:
- 通过FT-IR,XRD和TGA证实了奇托桑希夫基的成功合成,表明奇托桑氨基群和异环函数组之间的反应.
- 与纯基托相比,基托希夫基具有更高的热稳定性.
- 所有合成的希夫基都显示出显著的抗菌活性;通过超声波照射制备的基显示出增强的疗效.
- 使用超声波和4-oxo-4H-chromene-3-carbaldehyde合成的CSM4U Schiff基,与Gentamicin相比,表现出优越的抗菌活性 (19-27毫米抑制区) 和显著的抗真菌活性 (21毫米抑制区) 对抗Candida albicans和Candida tropicalis,超过了Terbinafine.
结论:
- 超声波辅助合成是一种有效的方法,用于制备具有增强抗菌特性的奇托希夫基.
- 合成的奇托桑希夫基具有作为抗微生物和抗真菌剂的巨大潜力.
- 在特定的测定中,CSM4U显示出有前途的治疗潜力,在特定的测定中超过现有的抗菌和抗真菌药物.
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