与催产素系统中的遗传和表观遗传变异相关的孕产妇结果:范围审查
Sarah R Weinstein1, Elise N Erickson1, Rodin Molina2,3
1University of Arizona College of Nursing, Tucson, AZ, USA.
Comprehensive psychoneuroendocrinology
|December 18, 2023
概括
催产素和催产素受体基因的遗传和表观遗传变异会影响母亲的照顾和心理健康. 早期的生活经历与遗传脆弱性相互作用,以塑造这些结果.
科学领域:
- 神经科学和遗传学 在神经科学和遗传学.
- 生殖健康 生殖健康
- 孕产妇心理健康 孕产妇心理健康
背景情况:
- 催产素及其受体在社会联系和母亲行为中起着至关重要的作用.
- 遗传和表观遗传因素可能会调节催产素对母亲结果的影响.
- 了解这些影响对于支持母亲健康至关重要.
研究的目的:
- 综合现有的关于催产素和催产素受体遗传和表观遗传变异的文献.
- 检查这些变异与母乳养,母乳护理和母亲心理健康之间的关系.
- 识别关键的遗传和表观遗传标记及其关联.
主要方法:
- 使用PRISMA指南进行了全面的范围审查.
- 文献搜索包括主要的数据库 (PubMed,EMBASE等). 使用特定的MeSH术语和关键词.
- 纳入标准侧重于同行评审的人类研究,报告与母亲结果相关的催产素/受体的遗传/表观遗传数据.
主要成果:
- 16项研究将遗传/表观遗传变异与母亲的心理健康联系起来,7项与照顾者行为联系在一起,4项与母乳养联系在一起.
- 催产素受体基因多态 rs53576 经常被研究并与产后抑郁症相关.
- 位点DNA甲基化 -934与母亲的抑郁和照顾行为相关.
结论:
- 催产素通路的遗传和表观遗传变异与母亲的照顾和心理健康有关.
- 复杂的基因环境相互作用,受到早期生活经验的影响,很可能参与其中.
- 这些发现强调了遗传学,环境和经验在孕产妇健康结果中的相互作用.
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