肝内胆管癌的分子向和全身疗法:一个多学科的方法
Katiuscha Merath1, Ankur Tiwari1, Alexander A Parikh1
1Division of Surgical Oncology, University of Texas Health Science Center San Antonio MD Anderson Cancer Center, San Antonio, TX, USA.
Future oncology (London, England)
|December 18, 2023
概括
肝脏内胆管癌 (ICC) 治疗的进展包括切除瘤的手术和晚期的化学疗法和免疫疗法等全身疗法. 分子向疗法为特定的基因组改变提供了新的选择.
科学领域:
- 肝胆道手术 肝胆道手术
- 医学瘤学 医学瘤学
- 基因组医学是基因组医学.
背景情况:
- 肝脏内胆管癌 (ICC) 往往是在晚期诊断出来的.
- 手术切除为切除的瘤提供治疗意图,其次是辅助性capecitabine.
- 无法切除/转移性ICC的全身治疗正在发展到超出标准化疗的范围.
研究的目的:
- 审查肝脏内胆管癌治疗的多学科方法.
- 强调目前和新兴的ICC系统和分子向疗法.
主要方法:
- 对目前ICC治疗策略的文献综述.
- 专注于手术,化疗,免疫治疗和分子向的方法.
- 讨论在ICC管理中的多学科护理.
主要成果:
- 用淋巴切除术切除R0是可切除ICC的标准.
- 开佩奇他是切割后标准的辅助疗法.
- 双重化学疗法 (gemcitabine和cisplatin) 是高级ICC的常见一线治疗方案.
- 三重疗法,免疫疗法和分子疗法是新兴的治疗选择.
结论:
- 肝内胆管癌的治疗需要采用多学科的方法.
- 系统疗法正在迅速发展,新的疗法和向药物正在迅速发展.
- 分子疗法已被批准用于可操作的基因组改变患者的二线治疗.
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