thiazolidinediones 使用与类风湿性关节炎发病率之间的关联:一项基于人口的回顾性队列研究
Houyu Zhao1, Xiaowei Chen2, Yexiang Sun3
1Peking University, Beijing, China.
Arthritis care & research
|December 18, 2023
概括
thiazolidinediones (TZDs) 可能降低类型 2 糖尿病 (T2DM) 患者的类风湿性关节炎 (RA) 风险. 这项研究发现,与阿尔法葡萄糖酶抑制剂相比,TZD使用与降低RA发病率有关.
科学领域:
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 临床前研究表明, thiazolidinediones (TZDs) 可能会提供对类风湿性关节炎 (RA) 的保护.
- 关于TZD对RA发病率的影响的基于人口的证据有限.
- 2型糖尿病 (T2DM) 患者代表了研究TZD对RA的影响的相关队列.
研究的目的:
- 调查 thiazolidinedione (TZD) 使用与类风湿性关节炎 (RA) 发生率之间的关联.
- 为了比较2型糖尿病患者 (T2DM) 发病TZD与α葡萄糖酶抑制剂 (AGIs) 的RA发病率.
主要方法:
- 追溯队列研究的设计.
- 在T2DM患者中包括TZD或AGI的新用户.
- 利用治疗权重的逆概率考克斯模型来估计RA发病率的危险比率 (HR).
主要成果:
- 分析包括56796名AGI用户和14892名TZD用户.
- 与AGI使用相比,TZD使用与减少RA发病率有关 (HR:0.72,95%CI:0.59-0.89).
- 累计使用TZD显示,在不同持续时间内持续降低了RA发病率的风险.
结论:
- thiazolidinedione (TZD) 的使用与2型糖尿病 (T2DM) 患者患类型2糖尿病 (RA) 的风险较低有关.
- 这些发现支持TZDs在T2DM患者的血糖控制之外的潜在疾病修饰作用.
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