降低调节的BMP-Smad1/5/8信号会通过膜II型上皮细胞的功能障碍引起肺气
Xi Zheng1,2, Xiaoying Chen1, Xiaoxiao Hu1
1Fujian Key Laboratory of Developmental and Neural Biology & Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, PR China.
下调 骨形态遗传蛋白 (BMP) -Smad1/5/8在肺细胞中的信号传递导致肺气. 恢复这种信号通路可以预防和逆转肺气,提供潜在的治疗点.
科学领域:
- 肺部医学 肺部医学
- 细胞生物学 细胞生物学
- 分子信号传输的方法
背景情况:
- 骨形态遗传蛋白 (BMP) -Smad1/5/8信号传递对于肺部发育和平衡至关重要.
- 它在肺病原发生中的作用尚不清楚.
研究的目的:
- 为了调查BMP-Smad1/5/8信号在肺瘤中的参与.
- 探索调节这种途径在肺气中的治疗潜力.
主要方法:
- 过度表达Noggin,一个BMP抗剂,在小鼠膜类型II上皮细胞 (AT2s) 中,以降低BMP-Smad1/5/8信号的调节.
- 评估突性表型,包括空气空间扩大,炎症,细胞外矩阵重塑和肺功能.
- 基因或化疗对BMP-Smad1/5/8信号的重新激活.
- 在香烟烟雾引起的肺瘤模型中分析BMP-Smad1/5/8信号.
主要成果:
- 在AT2s中降低BMP-Smad1/5/8信号的调节诱导了类似肺的表型,肺功能受损,炎症和改变表面活性蛋白质分泌.
- 重新激活BMP-Smad1/5/8信号减弱的肺病理和改善的肺功能.
- 在香烟烟雾引起的肺气中,BMP-Smad1/5/8信号被降低了.
- 增强BMP-Smad1/5/8活动在小鼠模型中预防或逆转肺气.
结论:
- BMP-Smad1/5/8信号传递是气膜干细胞功能和肺平衡的关键调节者.
- 这种途径的失调有助于瘤的发展.
- 针对BMP-Smad1/5/8信号提供了一个有前途的治疗策略,用于预防和治疗肺气.
更多相关视频
11:38Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay
Published on: September 14, 2021
10:37Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
Published on: January 16, 2015
相关概念视频
TGF - β Signaling Pathway
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
Breathing
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
The JAK-STAT Signaling Pathway
