在中年和老年自闭症成年人中增加抗胆固醇药物的使用及其与自我报告的记忆障碍和认知衰退的关联
Goldie A McQuaid1, Sean C Duane2, Neha Ahmed2
1Department of Psychology, George Mason University, Fairfax, Virginia, USA.
概括
自闭症成年人经常使用抗胆固醇 (AC) 药物,增加他们的记忆力投诉和认知能力下降的风险. 这项研究强调了这一群体中抗胆性认知负担 (ACB) 的显著程度.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 常见的药物具有抗胆性 (AC) 作用,与认知障碍和老年人患阿尔茨海默病的风险有关.
- 抗胆性认知负担 (ACB) 描述了AC药物的累积影响.
- 自闭症成年人可能面临由于同时出现的条件而增加的AC暴露,但AC对他们的认知的影响尚未研究.
研究的目的:
- 对于成年自闭症患者的AC药物暴露的特征.
- 检查AC暴露和自闭症成年人的认知结果之间的关联.
主要方法:
- 自闭症成年人 (40-83岁) 在第一时间自我报告药物使用和记忆障碍.
- 一个子组在2年的随访期间报告认知能力下降 (第二次).
- 药物被评估为AC强度;ACB被计算.
主要成果:
- 高比例 (48.2%-62.9%) 的自闭症成年人使用了AC药物;20.5%-26.5%报告了临床相关水平 (强度≥3).
- 较高的ACB分数和AC强度 (≥3) 预测了增加的记忆力投诉.
- 时间1使用AC药物与时间2自我报告的认知衰退有关.
结论:
- 自闭症成年人显着暴露于AC药物,导致抗胆固醇性认知负担.
- 在自闭症成年人中,AC药物使用与不良的认知结果有关,包括记忆力投诉和下降.
- 进一步研究包括多药在内的AC药物对自闭症成年人认知和痴呆风险的影响至关重要.
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