评估肥胖和慢性鼻炎的关联:系统性审查和元分析
David Hoying1,2, Katherine Miller1, Julia Tanzo1,2
1Head and Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
概括
这次元分析发现超重/肥胖和慢性鼻炎 (CRS) 之间存在联系. 较高的体重与增加的CRS患病率和升高的瘦素水平有关,这表明代谢联系.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 代谢综合征是代谢综合征的一种.
- 免疫学 免疫学 免疫学
背景情况:
- 慢性鼻炎 (CRS) 是一种具有复杂病理生理学的常见疾病.
- 超重/肥胖和代谢失调越来越多地被认为是导致炎症性疾病的潜在因素.
- 莱普是一种参与新陈代谢的激素,可能在CRS病变发生过程中发挥作用.
研究的目的:
- 对慢性鼻炎 (CRS),超重/肥胖和瘦素之间的关联进行全面的元分析和系统审查.
- 调查代谢失调和CRS之间的联系.
主要方法:
- 从1946年到2022年10月发表的研究的系统审查和元分析.
- 搜索了Ovid MEDLINE,Embase,科学网和科克兰控制试验中心注册表.
- 提取了CRS流行率和平均血清瘦素水平的几率比率;使用随机效应模型汇总了数据.
主要成果:
- 36项研究符合系统审查标准;其中6项被纳入了元分析.
- 在超重/肥胖和CRS患病率 (OR = 1.33) 之间发现了积极的关联.
- 与对照人群相比,CRS鼻多重症患者的平均血清瘦素水平显著更高 (平均值比率=2.21).
结论:
- 分析表明,超重/肥胖和慢性鼻炎之间存在显著的积极关联.
- 进一步的前性研究是有必要的,以阐明免疫机制和混杂的并发症.
- 了解代谢健康和CRS之间的联系可能会为未来的治疗策略提供信息.
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