动物菌 (Bifidobacterium animalis) 的亚种. 在患有自闭症的小鼠模型中,Probio-M8减轻了异常行为并调节了肠道微生物群
Zhuangzhuang Miao1,2, Lin Chen3, Yong Zhang4
1Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
mSystems
|December 18, 2023
概括
益生菌M8通过改善肠道细菌的多样性和新陈代谢,有效地治疗小鼠的自闭症症状. 这为自闭症干预提供了潜在的新途径.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 自闭症谱系障碍 (ASD) 在社交互动和重复行为方面存在挑战.
- 对于像自闭症这样的神经系统疾病的益生菌干预,研究有限.
- 益生菌对自闭症的影响的具体机制尚不清楚.
研究的目的:
- 为了研究*Bifidobacterium animalis*亚种的治疗作用. 在酸 (VPA) 诱导的自闭症小鼠模型上的 *lactis* Probio-M8.
- 探索Probio-M8对肠道微生物群多样性,代谢水平和与自闭症相关的行为症状的影响.
- 阐明Probio-M8缓解自闭症行为的潜在机制.
主要方法:
- 枪支元基因组学分析,以评估肠道微生物群的组成.
- 行为测试包括开放场,三室社交能力和新型物体识别测试.
- 分析代谢水平,包括胆和碳水化合物活性酶 (CAZy),以及血清神经递质.
主要成果:
- 在VPA诱导的小鼠中,Probio-M8治疗显著减少了自闭症行为,包括刻板印象的理和改善的社交互动和学习.
- 肠道微生物群的多样性得到了优化,有益细菌如*Bifidobacterium globosum*和*Akkermansia muciniphila*的丰富性增加.
- 观察到代谢调节,包括增加胆水平和纠正CAZy障碍,以及缓解神经递质失衡.
结论:
- *Bifidobacterium animalis* 亚种. 这种细菌可以在动物体内生长. *lactis* 益生菌M8在小鼠中显示了对VPA诱导的自闭症的治疗潜力.
- 益生菌M8通过调节肠道微生物组合和调节宿主代谢途径来发挥其作用.
- 这些发现表明益生菌是通过肠-大脑轴调节来管理自闭症症状的有希望的策略.
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