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Updated: Jul 8, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
除了三个P之外:上腺参与MEN1
Uriel Clemente-Gutierrez1, Carolina R C Pieterman2, Michael S Lui1
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
上腺病变 (ALs) 在多重内分泌瘤1型 (MEN1) 中很常见. 大多数ALs没有进展,但基于大小和生长速度,应该怀疑恶性瘤,这证明了激素的工作.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 上腺病变 (ALs) 经常在1型多重内分泌瘤 (MEN1) 患者中观察到.
- 对于MEN1中ALS的临床管理准则尚未得到充分确立.
- 了解ALS在MEN1中的患病率和行为对于患者护理至关重要.
研究的目的:
- 调查多发性内分泌新生病1型患者上腺病变的患病率和临床结果.
- 描述男性AL的成像特征和生长模式1.
- 为该群体中ALS的管理和工作提供建议.
主要方法:
- 在1990年至2021年间被诊断患有MEN1的患者的回顾性图表审查.
- 基于成像发现的ALS的分类 (单边/双边,结节/扩散,大小).
- 病变生长,激素功能和临床结果的分析.
主要成果:
- 在382名MEN1患者中,89名 (23.3%) 患有ALS,平均年龄为47岁.
- 确定了101个可测量的结节性病变,平均大小为17.5毫米;26.7%的病变小于1厘米.
- 放射性或临床进展的ALS是不常见的;恶性瘤被怀疑在显著的增长或大小的情况下. 在15.8%的受试者中发现了功能性病变.
结论:
- 在MEN1患者中,上腺损伤很常见,但通常表现为进展缓慢.
- 在AL中,应根据病变大小和生长速度怀疑恶性病变.
- 建议进行基线荷尔蒙工作;对于非功能性病变,不需要进一步的生物化学测试.
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