联合多金属暴露与骨质疏松症之间的关联
Lidong Qin1, Qiumei Liu1, Tiantian Zhang1
1Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Shuangyong Road 22, Nanning, 530021, Guangxi, China.
Biological trace element research
|December 18, 2023
概括
联合金属暴露会影响骨质疏松症的风险. 可能会降低风险,而,和会增加风险. 需要进一步的研究来了解这些金属的相互作用和机制.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 骨质疏松症是一个重大的公共卫生问题,其特点是骨质量低和骨折风险增加.
- 聚金属暴露越来越被认为是一个潜在的环境因素,影响各种健康结果,包括骨健康.
研究的目的:
- 调查血中多种金属的联合暴露与骨质疏松症风险之间的关联.
- 在一般人口样本中确定与骨质疏松症有显著相关的特定金属.
主要方法:
- 在2115名参与者中,使用诱导合血质谱法测量了22种金属的血度.
- 骨质疏松症的诊断是基于T-score ≤ -2.5.5的结果.
- 统计分析包括最小绝对收缩和选择操作员 (LASSO) 回归,二进制后勤回归和贝叶斯核机回归 (BKMR) 来建模金属骨质疏松症关联.
主要成果:
- 拉索回归在总人口和女性中发现了与骨质疏松症相关的10种金属,在男性中发现了4种金属.
- 后勤回归表明,较高的水平与骨质疏松症有负相关,而较高的和水平在总人口和妇女中具有正相关.
- BKMR模型证实了联合多金属暴露对骨质疏松症的整体积极影响,显示出保护作用,,和与风险增加有关.
结论:
- 血金属混合物与骨质疏松症风险有关.
- 可能起到对骨质疏松症的保护作用.
- 暴露于,和可能会增加患骨质疏松症的风险,因此需要进一步研究它们的机制.
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