在雌性周期期间的食氨酸补充剂改善了老鼠的卵泡发育和雌激素合成
Guangxin Yang1,2, Siyu Li1,2, Shuang Cai1,2
1State Key Laboratory of Animal Nutrition and Feeding, Ministry of Agriculture and Rural Affairs Feed Industry Centre, China Agricultural University, Beijing 100193, PR. China. wangfl@cau.edu.cn.
Food & function
|December 18, 2023
概括
食氨酸补充剂增强了老鼠的卵泡发育和雌激素合成,从而改善了胚胎植入. 这种营养策略可以提高动物的生殖性能.
科学领域:
- 生殖生物学 生殖生物学
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 毛囊对于类固醇激素合成和卵细胞发育至关重要.
- 氨酸对毛囊发育及其调节途径的确切影响仍然在很大程度上是未知的.
研究的目的:
- 研究食氨酸补充剂对大鼠毛囊发育和生殖结果的影响.
- 阐明调节 metionin 对卵巢功能的影响的潜在分子机制.
主要方法:
- 在雌性周期期间,给大鼠服用食氨酸补充剂.
- 分析了卵巢基因和蛋白质表达,血清氨基酸水平和代谢物度.
- 在体外研究中评估了 metionin 对卵泡发育和颗粒状细胞中雌激素合成的直接影响.
主要成果:
- 氨酸补充剂增加了胚胎植入部位和血清氨基酸.
- 观察到卵巢氨基酸载体,DNA甲基转移酶 (DNMTs) 和囊氨酸玛酶 (CSE) 的增强表达.
- 卵巢S-adenosylmethionine (SAM) 和谷氨 (GSH) 水平的增加,以及GDF9和BMP15的增强表达,促进了卵泡的发育.
- 氨酸通过上调颗粒状细胞中的关键基因来促进雌激素合成.
结论:
- 在大鼠中,食氨酸在雌激素周期期间促进卵泡生长和雌激素合成.
- 补充 metionin 通过增强胚胎植入来改善早期怀孕结果.
- 这项研究表明,氨酸是改善动物生殖表现的潜在营养策略.
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