对患有第一发精神病的人进行大麻减伤干预的评估:试点多中心随机试验的协议
Stephanie Coronado-Montoya1,2, Amal Abdel-Baki1,2,3, José Côté2,4
1Department of Psychiatry and Addiction, Université de Montréal, Montreal, QC, Canada.
JMIR research protocols
|December 18, 2023
概括
这项试点研究评估了CHAMPS,这是一款用于减少大麻危害的移动应用程序,用于首发精神病 (FEP) 的年轻人. 该研究评估了该应用程序在未来的大规模试验中的可接受性和可行性.
科学领域:
- 心理健康 心理健康
- 精神病研究 精神病研究
- 数字健康干预措施 数字健康干预措施
背景情况:
- 大麻使用在患有第一发精神病 (FEP) 的年轻人中普遍存在,结果恶化.
- 对于FEP而言,很少有基于证据的大麻干预措施,现有的干预措施有效性有限.
- 早期干预服务 (EIS) 努力解决FEP中存在问题的大麻使用问题.
研究的目的:
- 为患有FEP的个人开发和试点测试基于移动应用程序的大麻危害减少干预 (CHAMPS).
- 评估CHAMPS干预和全面试验的可接受性和可行性.
- 探索CHAMPS对使用大麻的FEP患者临床结果的影响.
主要方法:
- 一个多中心,双臂,并行组随机试验试验,涉及100名使用大麻的FEP年轻人.
- 参与者被随机分配1:1到CHAMPS + EIS或仅使用EIS.
- 通过完成率评估可接受性;通过保留率评估可行性;二次/探索性结果包括行为策略,动机,物质使用和症状严重程度.
主要成果:
- 招聘于2021年12月启动,数据收集和分析计划于2024年初完成.
- 关于CHAMPS可接受性和试验可行性的研究结果将提交同行评审出版.
- 关于可接受性和可行性的具体定量结果正在等待数据分析完成.
结论:
- CHAMPS集成了基于证据的方法,患者偏好和移动健康,以减少大麻危害.
- 积极的可接受性和可行性发现可以支持进一步的研究和更大的随机对照试验.
- 这项试点试验为大麻和早期精神病的可行和用户可接受的研究设计提供了宝贵的见解.
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