用于临床HIFU损伤检测的被动弹性学
IEEE transactions on medical imaging
|December 18, 2023
概括
作为一种新型超声波技术的被动弹性学,通过检测组织硬化,有效地监测高强度聚焦超声波 (HIFU) 治疗. 这种方法有望改善HIFU治疗,特别是前列腺癌,通过提供可靠的除监测.
科学领域:
- 医疗成像医学成像
- 超声波技术 超声波技术 超声波技术
- 生物医学工程 生物医学工程
背景情况:
- 高强度聚焦超声波 (HIFU) 显示了治疗前列腺癌等疾病的潜力.
- 目前对HIFU的超声波监测是有限的,通常依赖于泡检测.
- 由HIFU引起的组织硬表明弹性体作为一种可行的监测方法.
研究的目的:
- 评估 HIFU 诱导的组织变化监测的被动弹性学.
- 评估使用临床超声波系统的被动弹性学可行性.
- 调查被动弹性图的潜力,以实时监测HIFU剥离的可能性.
主要方法:
- 被动弹性图形适应处理临床B模式超声图像.
- 使用Focal One®系统对校准的幻影和体外实验进行验证.
- 在猪肝中的体内研究和前列腺癌患者的初步临床应用.
主要成果:
- 被动弹性学准确地评估了幽灵的弹性.
- 在体外,它检测到HIFU病变独立于泡形成 (CNR = 9.2 dB).
- 在体内,它成功地划分了猪肝中的病变,并在HIFU后的前列腺癌患者中显示出显著的弹性变化 (33.0 ± 16.0%).
结论:
- 被动弹性学是一种有前途的技术,用于监测HIFU治疗.
- 它提供了一种可靠的,基于超声波的方法来评估剥离.
- 这种技术可以促进HIFU治疗的更广泛的临床采用.
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