丁酸盐缓解高脂肪诱导的代谢障碍,部分是通过增加系统性谷氨胺
Zeyu Fan1,2, Shaonan Wang1,2, Yingying Meng1,2
1College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Journal of agricultural and food chemistry
|December 18, 2023
概括
酸通过增加谷氨胺水平来对抗与肥胖相关的代谢障碍. 这项研究揭示了丁酸盐如何有益于代谢平衡,提供了一条新的治疗途径.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 肥胖研究的研究.
- 营养生物化学 营养生物化学
背景情况:
- 肥胖是一个全球性流行病,具有重大代谢后果.
- 已知丁酸盐和谷氨酸可以抵消代谢障碍.
- 在肥胖中,丁酸盐和谷氨胺之间的协同相互作用仍然没有被阐明.
研究的目的:
- 研究丁酸盐和谷氨酸在对抗与肥胖相关的代谢障碍方面的潜在协同作用.
- 在高脂肪饮食诱导的肥胖模型中阐明丁酸盐有益作用的潜在分子机制.
主要方法:
- 在小鼠中建立了一个高脂肪饮食 (HFD) 模型,以诱导肥胖和代谢障碍.
- 通过口腔液,小鼠接受了酸盐 (SB) 或盐水的治疗.
- 使用有针对性的质谱和基因表达分析来评估代谢参数和分子变化.
主要成果:
- 在HFD小鼠中,酸丁的使用显著降低了体重,脂肪量和肝脏甘油三含量.
- SB治疗恢复了血清谷氨胺水平,HFD减少了这种水平.
- SB肝脏氨酸合成酶 (GS) 表达率升高,与*GLUL*促进体中H3K27ac修饰的增加有关.
结论:
- 增加的谷氨胺有助于高脂肪饮食引起的肥胖症中酸盐的有益代谢作用.
- 这项研究发现了一种涉及谷氨酸提升的新途径,通过该途径,丁酸盐可以改善代谢平衡.
- 这些发现表明,针对酸盐-谷氨胺轴的潜在治疗策略可以用于管理与肥胖相关的代谢障碍.
相关概念视频
01:21Drugs for Treatment of Constipation-Predominant IBS
176
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
176
01:24Overview of Lipid Metabolism
1.6K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.6K
01:25Metabolic States of the Body: The Absorptive State
694
During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...
694
01:26Glucose Absorption Into the Small Intestine
31.7K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.7K