哺乳动物中脑 (中枢神经系统的中间部门) 的内在电路
Larry W Swanson1, Joel D Hahn1, Olaf Sporns2,3
1Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089.
概括
这项研究绘制了老鼠的脑 (后脑) 网络,显示只有15.4%的可能连接存在. 一个层次模型识别了关键的子系统,提供了对大脑结构功能关系的见解.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 脑 (后脑) 是脊椎动物中枢神经系统的一个关键组成部分.
- 它包括pons,小脑和髓,位于前脑 - 中脑和脊髓之间.
- 了解其内在网络架构对于破译大脑功能至关重要.
研究的目的:
- 用数据驱动的方法研究大鼠rhombencephalon的内在网络架构.
- 根据连接性,开发一个基于rhombencephalon子系统的层次模型.
- 为了比较rhombencephalon的网络架构与前脑中脑.
主要方法:
- 分析大鼠脑中230个灰质区域之间的内在轴突连接.
- 应用多解决方案共识集群分析来识别网络子系统.
- 单个和组合的罗姆脑区分的颗粒状网络分析.
主要成果:
- 在52,670个可能的轴突连接中,只有8,089个 (15.4%) 存在于罗姆本脑内.
- 一个嵌套的等级模型揭示了与小脑/前置细胞核,口面-喉-内脏整合和听觉连接相关的顶级子系统.
- 网络架构表现出随着连接的加法或减法而变化的可变性,显示出与前脑中脑架构的差异.
结论:
- 识别的等级模型为在rhombencephalon.com内生成和测试功能假设提供了一个框架.
- 这项研究突出显示了脑和前脑-中脑之间独特的结构-功能网络架构.
- 对区域间连接的进一步分析将有助于建立一个全面的哺乳动物大脑神经网络模型.
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