检查多巴胺在甲基酸对休息时大脑功能影响中的作用
Dardo Tomasi1, Peter Manza1, Weizheng Yan1
1Laboratory of Neuroimaging (LNI), National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892.
甲基 (MP) 改变大脑活动,静脉注射MP显著影响低频波动 (ALFF) 和全球功能连接密度 (gFCD) 的幅度. 增强的gFCD与多巴胺水平和上升率相关,而减少的ALFF与多巴胺水平相关.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 神经成像是一种神经成像.
背景情况:
- 低频波动的幅度 (ALFF) 和全球功能连接密度 (gFCD) 是评估大脑功能的关键功能性MRI (fMRI) 度量.
- ALFF和gFCD对兴奋剂诱导的多巴胺 (DA) 增加的差异敏感性,以及它们之间的关系,仍未得到充分研究.
研究的目的:
- 为了研究状多巴胺和大脑活动 (ALFF和gFCD) 在甲 (MP) 管理后的动态变化之间的联系.
- 检查ALFF和gFCD对MP诱导的多巴胺增加速度和水平的差异敏感性.
主要方法:
- 同时位子发射断层成像-fMRI (PET-fMRI) 被采用在受试者内部,双盲,安慰剂控制的设计中.
- 参与者接受了安慰剂,静脉注射 (IV) -MP或口服MP.
- 测量了纹状D2/3受体可用性,ALFF和gFCD的变化.
主要成果:
- 静脉注射MP显著降低了D2/3受体的可用性,ALFF,并增加了门中的gFCD (科恩d>1.6). 口服MP的效果较小 (科恩d<0.6).
- 增强的gFCD与状DA增加的水平和速度有关.
- 降低ALFF仅与DA增加水平有关. 通过IV-MP加强了gFCD和ALFF之间的反向关联.
结论:
- ALFF和gFCD表现出刺激剂诱导的多巴胺增加的独特的神经血管表征,对多巴胺水平和上升率的敏感性不同.
- 这些发现表明,MP的血管活性特性可能有助于观察到gFCD和ALFF之间的反向关系.
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