低细胞毒性,广谱玉米粉基抗菌颗粒抑制多药耐药细菌
Bin Deng1,2, Jun Gu1, Shuaifeng Zhang1
1Key Laboratory of Veterinary Biological Engineering and Technology Ministry of Agriculture, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.
ACS applied bio materials
|December 18, 2023
概括
研究人员开发了新的HTCC/粉颗粒,作为抗生素的低细胞毒性替代品. 这些颗粒对抗耐药细菌表现出广泛的抗微生物活性,为打击抗微生物耐药性提供了有前途的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 微生物学 微生物学
- 药物发现 药物发现 药物发现
背景情况:
- 抗菌素耐药性 (AMR) 对生物医学应用构成重大威胁,增加了治疗失败的风险.
- 开发有效的抗菌剂对抗多药耐药 (MDR) 细菌是一个关键的研究目标.
研究的目的:
- 设计和制备一种新的,低细胞毒性,高效的替代传统抗生素.
- 评估开发剂对各种细菌菌株的抗菌疗效和稳定性,包括MDR病原体.
主要方法:
- 可食用的玉米粉被用作支架,功能化使用2-基基酸 (HTCC) 作为抗菌剂.
- 由此产生的HTCC/粉颗粒因其表面电荷,抗微生物特性对抗阳性和阴性细菌以及在模拟胃液 (SGF) 中的稳定性而具有特征.
主要成果:
- HTCC/粉颗粒在广泛的pH范围内表现出稳定的正表面电荷.
- 这些颗粒显示出广泛且高效的抗菌活性,对抗标准细菌菌株和临床MDR菌株.
- 这些颗粒在暴露于SGF (pH1.2) 后有效抑制了MDR *Escherichia coli*的生长,表明胃酸耐受性.
结论:
- HTCC/粉颗粒代表了一种潜在的成本效益和可行的替代抗生素来解决AMR.
- 它们对病原性肠道细菌的有效性和对胃酸状况的耐受性使它们在向肠道微生物群的应用中特别有希望.
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