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Updated: Jul 8, 2025

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生物活性螺旋的高亲和度结合剂的新设计

Susana Vázquez Torres1,2,3, Philip J Y Leung1,2,4, Preetham Venkatesh1,2,3

  • 1Department of Biochemistry, University of Washington, Seattle, WA, USA.

Nature
|December 18, 2023
PubMed
概括

科学家开发了新的人工智能方法来设计与柔性激素结合的蛋白质. 这些蛋白质结合剂可以检测甲状腺激素和葡萄糖等激素,帮助治疗疾病.

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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