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开发基于两性环氧的纳米颗粒,用于输送活性物质

Luc Augis1, Ingeborg Nerbø Reiten2, Jan-Lukas Førde3

  • 1Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400 Orsay, France.

International journal of pharmaceutics
|December 18, 2023
PubMed
概括

这项研究提出了一种使用矿物基催化产生两性环极衍生物 (ACD) 的新方法,使得纳米医学中可控制纳米颗粒的形成. 合成的纳米颗粒显示出良好的生物相容性和生物分布特征.

关键词:
两性循环克斯林是什么?补充激活的激活方式纳米颗粒 纳米颗粒通过PEGylation进行化.斑马鱼的幼虫 斑马鱼的幼虫

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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