SAH和SAM/SAH比率与重症患者的急性损伤有关:一个病例对照研究
Zhini Liu1, Xiaona Li2, Tiehua Wang3
1Department of Pharmacy, Peking University Third Hospital, Beijing 100191, China; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu Province 211198, China; Therapeutic Drug Monitoring and Clinical Toxicology Center of Peking University, Beijing 100191, China.
Clinica chimica acta; international journal of clinical chemistry
|December 18, 2023
概括
急性损伤 (AKI) 与血和尿液中的甲基化代谢物发生变化有关. 像S-adenosylhomocysteine (SAH) 和SAM/SAH比率这样的特定代谢物与功能有很强的相关性,可以帮助区分AKI患者.
科学领域:
- 生物化学 生化学
- 临床化学 临床化学
- 代谢学 代谢学 代谢学
背景情况:
- 急性损伤 (AKI) 是一个重大的临床挑战,死亡率高.
- 异常的DNA甲基化和改变的代谢物与病进展有关.
- 在AKI患者中,特定的甲基化相关代谢物变化需要进一步阐明.
研究的目的:
- 在AKI患者的血和尿液中研究和量化特定的甲基化相关代谢物.
- 评估这些代谢物和功能指数之间的相关性.
- 评估这些代谢物对AKI的诊断潜力.
主要方法:
- 倾向性得分匹配被用于招募61名AKI和61名非AKI住院患者.
- 超高性能液态染色学-并联质谱学 (UHPLC-MS/MS) 量化了11种甲基化相关代谢物.
- 进行了相关性,ROC和二进制回归分析.
主要成果:
- 血代谢物包括S-adenosylhomocysteine (SAH) 和S-adenosylmethionine (SAM) /SAH比率与血清肌素 (SCr) 和估计的淋巴膜过率 (eGFR) 强烈相关.
- 血SAH和尿液SAM/SAH比率在区分AKI方面表现出高准确性.
- 血和尿液中的特定代谢物变化作为AKI的风险或保护标记.
结论:
- 对血和尿液的全面分析显示,AKI中存在广泛的甲基化代谢变化.
- 血SAH,血和尿液SAM/SAH比率与功能有很强的相关性,有效地区分AKI.
- 这些发现为预测功能下降和了解AKI病原体提供了有希望的生物标志物.
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