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研究进展中,有毒的传统草药来自Thymelaeaceae的毒性研究进展
Lingnan Zhao1, Yanping Zhang1, Qianqian Yin1
1School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Journal of ethnopharmacology
|December 18, 2023
概括
传统的草药来自Thymelaeaceae家族显示出治疗癌症等疾病的希望,但具有显著的毒性. 对它们的有毒化合物和解毒方法的研究对于安全的临床应用至关重要.
科学领域:
- 药理学和民族植物学
- 毒理学 毒理学 毒理学
- 药用化学 医学化学
背景情况:
- 泰米兰花家族植物在热带和温带地区被广泛用作传统草药.
- 这些植物已经证明了治疗包括白血病,艾滋病和肝癌等疾病的治疗潜力.
- 然而,大约20%的这些物种表现出不良影响,如致癌性和器官损伤.
研究的目的:
- 审查Thymelaeaceae家族中的传统草药的有毒副作用,化合物,机制和排毒策略.
- 为这些药用植物的安全临床使用提供指导.
主要方法:
- 进行了全面的文献搜索,使用关键词如"Thymelaeaceae"",毒性"和特定的属/物种名称.
- 搜索的数据库包括Pubmed,SciFinder Scholar,Elsevier,Web of Science和CNKI,涵盖了截至2023年6月的信息.
- 使用"世界植物在线"验证了植物命名.
主要成果:
- 在Thymelaeaceae家族中的13个属中的28种有毒的传统草药被识别和分类.
- 在细胞,动物和临床水平上记录了有毒作用,其中烯被确定为主要的有毒成分,特别是在Daphne L.和Wikstroemia Endl.中. 一般化. 一般化.
- 线粒体通路被认为是主要的毒性机制,而加工和汗水浸泡等加工方法显示出排毒和提高疗效的潜力.
结论:
- 泰米兰属植物药用植物具有显著的药理作用,特别是抗艾滋病毒和抗瘤特性.
- 这些植物固有的毒性对其临床应用提出了重大挑战.
- 对有毒成分,机制和先进的解毒方法进行进一步的研究是必不可少的,以释放Thymelaeaceae传统草药的全部治疗潜力.
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