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基于金属有机框架的先进治疗工具用于抗微生物应用

Zhao Chen¹, Fei Xing¹, Peiyun Yu²

¹Department of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.

Acta biomaterialia

|December 18, 2023

概括

金属有机框架 (MOF) 提供了超越传统抗生素的新型抗菌策略. 本综述详细介绍了MOF的合成,机制和应用,用于治疗诸如伤口感染和骨髓炎等感染.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

传统的抗生素面临着日益增长的耐药性,需要新的抗菌剂.
金属有机框架 (MOFs) 由于其可调节的结构和多样化的抗菌性质而具有前景.

研究的目的:

提供对MOF合成和抗菌机制的全面审查.
探索基于MOF的抗微生物策略及其临床应用的进展.

主要方法:

关于MOF合成和抗菌机制的文献综述.
在伤口感染,骨髓炎和牙周炎中对MOF应用的分析.

主要成果:

MOFs通过持续释放剂,反应性氧物种 (ROS) 生产和光生成的ROS表现出抗菌活性.
基于MOF的材料在治疗各种感染方面取得了进展,包括伤口感染和骨髓炎.

结论:

MOFs为开发下一代抗菌材料提供了一个多功能平台.
对MOF应用的进一步研究可以克服对抗抗生素耐药性的挑战.

关键词:

抗菌的应用抗菌的应用抗菌材料是一种抗菌材料.MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF MOF 金属有机框架的框架.纳米材料是一种纳米材料.

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