在高饮食的健康正常压力成年人中,补充黑素不会改变血管功能或氧化应激
Macarena Ramos Gonzalez1, Michael R Axler1, Kathryn E Kaseman1
1Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.
Physiological reports
|December 18, 2023
概括
高饮食可以通过增加活性氧物种 (ROS) 来损害血管功能. 在10天高饮食期间,黑素补充剂没有改善血管功能或减少健康成年人的ROS.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 高饮食 (HSD) 与血管功能障碍和活性氧物种 (ROS) 的增加有关.
- 作为一种抗氧化剂的氨酸可以减轻这些影响,并改善血管健康.
- 在HSD期间,黑激素对血管功能的影响需要进一步研究.
研究的目的:
- 为了研究黑激素补充剂对血管功能和ROS水平在个体消耗HSD的影响.
- 测试黑色素可以改善血管功能和减少ROS在HSD期间的假设.
主要方法:
- 一个随机对照试验,涉及27名健康成年人 (13M/14W).
- 参与者每天接受10毫克氨酸或安慰剂的10天HSD (6900毫克/天) 治疗.
- 使用臂动脉流量介导扩张和组织氧化指数 (TSI) 反率来评估血管功能.
主要成果:
- 黑素补充剂没有显著改变手臂动脉流介导扩张 (p=0.59).
- 微血管反应率,以 TSI 重灌率 (p=0.97) 和 TSI 曲线下的面积 (p=0.17) 来衡量,保持不变.
- 氧化物度 (p=0.55) 和自由基数 (p=0.51) 两组之间没有差异.
结论:
- 黑素补充剂没有显示出对健康年轻成年人HSD的宏血管或微血管功能有显著影响.
- 这项研究表明,黑激素可能无法抵消这种人群中短期HSD的血管效应.
- 需要进一步的研究来探索黑激素在不同人群或慢性HSD条件下的作用.
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