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一个扩展的贝叶斯半机械剂量检测设计用于I期瘤学试验,使用药理动力学和药理动力学信息

Chao Yang1, Yisheng Li1

  • 1Department of Biostatistics, Division of VP, Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Statistics in medicine
|December 18, 2023
PubMed
概括

这项研究引入了一种用于瘤学试验的新型半机械剂量检测设计,整合了药理动力学/药理动力学 (PK/PD) 数据,以改善剂量毒性建模,并更准确地确定最大耐受剂量 (MTD).

关键词:
细胞因子释放综合征 细胞因子释放综合征发现剂量发现剂量在剂量-毒性曲线上.最大的耐受剂量.药理动力学是药理动力学的一个方面.药物动力学 药物动力学

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